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Activated by the antibiotic rifampicin and a variety of plant metabolites, for example hyperforin, guggulipid, colupulone, and isoflavones. Reaction to unique ligands is species-particular. Activated by naturally transpiring steroids, like pregnenolone and progesterone. Binds to your reaction element within the promoters on the CYP3A4 and ABCB1/MDR